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Systemic glutamate induces degeneration of a subpopulation of serotonin-immunoreactive neurons in the area postrema of rats

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
117
Identifiers
DOI: 10.1016/0304-3940(90)90115-p
Keywords
  • Neuroexcitotoxicity
  • Glutamate
  • Immunocytochemistry
  • Serotonin
  • Circumventricular Organ
  • Area Postrema

Abstract

Abstract Neuronal damage in the area postrema (AP) of adult Sprague-Dawley rats was induced by subcutaneous administration of monosodium glutamate (MSG; 9 mg/g b.wt.). Serotonin-immunoreactive (5-HT-IR) neurons were visualized in the AP 3 h or 7 days after control or MSG treatment. At 3 h post MSG, many 5-HT-IR neurons showed morphological signs of degeneration, such as, cytoplasmic vacuolization, chromatin clumping and dendritic hypertrophy. MSG treatment caused a 30% reduction of detectable AP 5-HT neurons after 7 days. We conclude that a subpopulation of serotonergic neurons in the AP is sensitive to the neuroexcitotoxic effect of systemic glutamate.

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