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Changes in the levels of different ions in the eggshell gland lumen followingp,p′-DDE-induced eggshell thinning in ducks

Authors
Journal
Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology
0742-8413
Publisher
Elsevier
Publication Date
Volume
109
Issue
1
Identifiers
DOI: 10.1016/0742-8413(94)00040-h
Keywords
  • Dde
  • Eggshell
  • Shell Gland
  • Duck
  • Prostaglandins
  • Uterine Fluid
  • Calcium
  • Bicarbonate
  • Atpase

Abstract

Abstract Eggshell thinning in ducks was induced by administration of p, p′-DDE in the diet (40 mg/kg food) for 45 days. This treatment resulted in a 19% reduction of the Eggshell Index (EI). Shells from calcifying eggs obtained at the time of slaughter showed a 36% reduction of EI. Prostaglandin synthesis by a homogenate of eggshell gland mucosa from p, p′-DDE-treated ducks was reduced by 24%. HCO 3 − -stimulated ATPase activity by a homogenate of eggshell gland mucosa from p, p′-DDE-treated ducks was not significantly changed. The calcium content of eggshell gland mucosa was increased to 127% in p, p′-DDE-treated ducks. p, p′-DDE-treated ducks showed profound changes in the shell gland luminal content of several ions. Calcium (−43%), sodium (−15%), potassium (−15%), bicarbonate (−33%) and chloride (−29%) were all significantly reduced in p, p′-DDE-treated ducks. The content of phosphate was unchanged. These findings are discussed in relation to a proposed mechanism for p, p′-DDE-induced eggshell thinning that involves inhibition of prostaglandin synthesis in eggshell gland mucosa.

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