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Cellular diversity promotes intercellular Ca2+wave propagation

Authors
Journal
Biophysical Chemistry
0301-4622
Publisher
Elsevier
Publication Date
Volume
139
Issue
1
Identifiers
DOI: 10.1016/j.bpc.2008.10.001
Keywords
  • Ca2+Waves
  • Diversity-Induced Resonance
  • Cellular Variability
  • Coupled Cells
Disciplines
  • Communication
  • Mathematics

Abstract

Abstract Calcium ions are an important second messenger in living cells. Calcium signals in form of waves serve as a means of intercellular communication and thus represent a vibrant subject for experimental and theoretical investigations. Here we study the role of cellular variability on the occurrence of Ca 2+ wave propagation in a net of diffusively coupled cells. Dynamics of individual cells is simulated by a mathematical model for Ca 2+ oscillations. Structural diversity of cells is introduced via variations of the bifurcation parameters, which signify cell sensitivity for external stimulation. Remarkably, for sufficient values of variability Ca 2+ waves emerge, which are mostly ordered for intermediate variability strength. We analyze the spatial profile via the autocorrelation function, which confirms a resonance-like response due to the cellular variability. Thus, the reported phenomenon is a novel observation of diversity-induced spatial coherence resonance in a tissue-like media.

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