Affordable Access

Publisher Website

Intravenous Magnesium as an Adjuvant in Acute Bronchospasm: A Meta-Analysis

Authors
Journal
Annals of Emergency Medicine
0196-0644
Publisher
Elsevier
Volume
36
Issue
3
Identifiers
DOI: 10.1067/mem.2000.109170
Disciplines
  • Medicine

Abstract

Abstract Study Objective: Although several trials have been published evaluating intravenous magnesium sulfate as treatment for acute bronchospasm, its effectiveness for this indication remains unclear, prompting this meta-analysis. Methods: All randomized controlled trials of adjuvant bolus intravenous magnesium sulfate for acute bronchospasm in the emergency department were eligible. Trials were identified using MEDLINE, EMBASE, bibliographies of selected articles, and review of abstracts of 4 scientific societies. Two reviewers abstracted data, one of whom was blinded to author and journal. Because studies used different spirometric outcome measures, effect size was calculated for each study by Hedges’ method. The analysis used a fixed-effects model. One-way sensitivity analyses were performed to assess the influence of study quality and to search for publication bias. Results: Abstracts from 210 articles were reviewed, yielding 40 trials, of which 9 were specific to bolus intravenous magnesium sulfate in the ED, in doses from 1.2 to 2 g, or an equivalent pediatric dose. Combined results across 9 studies including 859 patients showed a posttreatment effect size of 0.162 for patients treated with intravenous magnesium sulfate (95% confidence interval 0.028, 0.297; P =.02). In sensitivity analyses exploring the effects of study quality and publication bias, the summary effect ranged from 0.127 to 0.206. No serious adverse events were reported. Conclusion: Adjuvant bolus intravenous magnesium sulfate in acute bronchospasm appears statistically beneficial in improving spirometric airway function by 16% of a SD. Although the clinical significance of this is uncertain, given the safety of intravenous magnesium sulfate therapy and its relatively low cost, it should be considered, absent contraindications, in patients with moderate to severe acute bronchospasm. [Alter HJ, Koepsell TD, Hilty WM. Intravenous magnesium as an adjuvant in acute bronchospasm: a meta-analysis. Ann Emerg Med. September 2000;36:191-197.]

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Intravenous magnesium as an adjuvant in acute bron...

on Annals of Emergency Medicine September 2000

A meta-analysis on intravenous magnesium sulphate...

on Archives of Disease in Childho... January 2005

Intravenous and nebulised magnesium sulphate for a...

on Emergency medicine journal : E... December 2007
More articles like this..