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The glucose-regulated protein grp94 is related to heat shock protein hsp90

Authors
Journal
Journal of Molecular Biology
0022-2836
Publisher
Elsevier
Publication Date
Volume
194
Issue
2
Identifiers
DOI: 10.1016/0022-2836(87)90380-9
Disciplines
  • Biology

Abstract

Abstract We report the sequence of a cDNA clone that encodes the C-terminal half of the hamster 94 × 10 3 M r glucose-regulated protein, grp94. The amino acid sequence of this protein is about 50% homologous to Drosophila hsp83 and yeast hsp90, suggesting that grp94 and hsp90 have similar functional properties. Unlike hsp90, grp94 is associated with the endoplasmic reticulum. It has the same C-terminal tetrapeptide as two other luminal endoplasmic reticulum proteins, grp78 and protein disulphide isomerase. We suggest that this sequence forms part of a signal for retention of proteins in the lumen of the endoplasmic reticulum.

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