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Harman and norharman: Induction of sister-chromatid exchanges in human peripheral lymphocytes in vitro and interaction with isolated DNA

Authors
Journal
Mutation Research/Genetic Toxicology
0165-1218
Publisher
Elsevier
Publication Date
Volume
90
Issue
4
Identifiers
DOI: 10.1016/0165-1218(81)90065-3

Abstract

Abstract Harman, but not norharman, induced sister-chromatid exchanges in human peripheral lymphocytes in vitro. Transcription of isolated DNA in vitro was inhibited by both compounds, harman being more effective than norharman. A filter-binding assay with isolated DNA showed that harman binds more effectively to the DNA than norharman.

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