Affordable Access

Potential and clinical utility of stem cells in cardiovascular disease

Authors
Publisher
Dove Press
Publication Date
Keywords
  • Stem Cells And Cloning: Advances And Applications
Disciplines
  • Biology
  • Engineering
  • Medicine

Abstract

Korff Krause, Carsten Schneider, Kai Jaquet, Karl-Heinz KuckHanseatic Heart Center Hamburg, Department of Cardiology, Asklepios Hospital St. Georg, Hamburg, GermanyAbstract: The recent identification of bone marrow-derived adult stem cells and other types of stem cells that could improve heart function after transplantation have raised high expectations. The basic mechanisms have been studied mostly in murine models. However, these experiments revealed controversial results on transdifferentiation vs transfusion of adult stem cells vs paracrine effects of these cells, which is still being debated. Moreover, the reproducibility of these results in precisely translated large animal models is still less well investigated. Despite these weaknesses results of several clinical trials including several hundreds of patients with ischemic heart disease have been published. However, there are no solid data showing that any of these approaches can regenerate human myocardium. Even the effectiveness of cell therapy in these approaches is doubtful. In future we need in this important field of regenerative medicine: i) more experimental data in large animals that are closer to the anatomy and physiology of humans, including data on dose effects, comparison of different cell types and different delivery routes; ii) a better understanding of the molecular mechanisms involved in the fate of transplanted cells; iii) more intensive research on genuine regenerative medicine, applying genetic regulation and cell engineering.Keywords: stem cells, cardiovascular disease

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Potential and clinical utility of stem cells in ca...

on Stem Cells and Cloning Advance... Jan 01, 2010

Potential and clinical utility of stem cells in ca...

on Stem cells and cloning : advan... 2010

The Potential of Stem Cells in the Treatment of Ca...

on Stem Cell Reviews and Reports Jan 01, 2013
More articles like this..