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Pathology of Intestinal Motor Disorders in Children

Authors
Journal
Surgical Pathology Clinics
1875-9181
Publisher
Elsevier
Publication Date
Volume
3
Issue
3
Identifiers
DOI: 10.1016/j.path.2010.06.005
Keywords
  • Intestinal Pseudo-Obstruction
  • Hirschsprung Disease
  • Hypoganglionosis
  • Neuronal Dysplasia
  • Visceral Myopathy
  • Visceral Neuropathy
  • Dysmotility
  • Rectal Biopsy
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Varied intestinal neuromuscular pathologies are responsible for Hirschsprung disease and other forms of chronic pseudo-obstruction that are encountered in pediatrics. Pathologically distinct subtypes discussed in this review include aganglionosis, hypoganglionosis, neuronal intranuclear inclusion disease, ganglionitis, degenerative neuropathy, diffuse ganglioneuromatosis, neuronal dysplasia, malformations of the muscularis propria, degenerative leiomyopathy, leiomyositis, and mitochondriopathies. Emphasis is given to the histopathologic features that distinguish these conditions and their differential diagnoses.

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