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DFT and ab initio potential energy scan and hydrogen bond analysis of Nα-substituted hydrazino acetamides: Characterization of the “hydrazinoturn” hydrogen bonding pattern

Authors
Journal
Journal of Molecular Structure THEOCHEM
0166-1280
Publisher
Elsevier
Publication Date
Volume
911
Identifiers
DOI: 10.1016/j.theochem.2009.07.003
Keywords
  • Potential Energy Scan
  • Hydrogen Bond
  • Nα-Substituted Hydrazino Acetamides
  • Hydrazinoturn
Disciplines
  • Computer Science

Abstract

Abstract We studied a series of model primary amides in gas phase at the DFT (B3LYP) and HF at 6-31+G/6-31+G∗∗ levels of theory in order to shed light on their conformation, structure, and intramolecular hydrogen bonding network. A potential energy scan was performed by rotating around the appropriate bond for each molecule studied in this paper. In this manner, it was possible to show that the amidic group of these model compounds acts as H-bond donor and interacts with two different H-bond acceptors which stabilizes a C 8 pseudocycle, the so called “hydrazinoturn”. This study was addressed theoretically in order to understand the conformation adopted by hydrazino acetamides as model compounds for aza-β 3-peptides. We thus investigated the conformational analysis of hydrazinoturns computationally and showed that these systems represent a very stabilizing folding driving force, provided that the neighboring molecular functional groups do not imply other competing hydrogen bonding patterns.

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