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Complete exon-intron organization of the mouse fibulin-1 gene and its comparison with the human fibulin-1 gene

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
444
Issue
1
Identifiers
DOI: 10.1016/s0014-5793(99)00024-1
Keywords
  • Fibulin-1
  • Gene Structure
  • Extracellular Matrix
  • Alternative Splicing
Disciplines
  • Biology

Abstract

Abstract Fibulin-1 is a 90 kDa calcium-binding protein present in the extracellular matrix and in the blood. Two major variants, C and D, differ in their C-termini as well as the ability to bind the basement membrane protein nidogen. Here we characterized genomic clones encoding the mouse fibulin-1 gene, which contains 18 exons spanning at least 75 kb of DNA. The two variants are generated by alternative splicing of exons in the 3′ end. By searching the database we identified most of the exons encoding the human fibulin-1 gene and showed that its exon-intron organization is similar to that of the mouse gene.

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