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Chlorophenothane (DDT) and glutamine in pentylenetetrazole (cardiazole) convulsions in the rat

Authors
Journal
Toxicology and Applied Pharmacology
0041-008X
Publisher
Elsevier
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1016/0041-008x(64)90111-5

Abstract

Abstract 1,1-Dichloro-2,2-bis( p-chlorophenyl) ethylene (DDE); 2,2-bis( p-chlorophenyl) acetic acid (DDA); bis( p-chlorophenyl)methane; 4,4′-dichlorobenzhydrol; 4,4′-dichlorobenzophenone; chlorobenzene, and p-chlorobenzoic acid given orally and glutamine given intravenously to rats did not protect the animals against a pentylenetetrazole convulsive dose of 80 mg/kg given subcutaneusly. None of these substances could explain the weak anticonvulsive effect of DDT which develops 2 or 3 days after its oral administration.

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