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The pharmacology of the isolated foregut of the locustSchistocerca gregaria—II. characterization of a 5-HT2-like receptor

Authors
Journal
Comparative Biochemistry and Physiology Part C Comparative Pharmacology
0306-4492
Publisher
Elsevier
Publication Date
Volume
88
Issue
1
Identifiers
DOI: 10.1016/0742-8413(87)90057-0

Abstract

Abstract 1. 5-HT (10 −8−5 × 10 −6 M) relaxed isolated locust foreguts. 2. The effects of 5-HT were mimicked by 5,6-DHT, 5-MeOT, tryptamine, 5-MeT, MK212 and methysergide while 5-hydroxyindole, 5-hydroxyindole acetic acid, 5-hydroxytryptophol, NN-DMT, 8-OH DPAT and RU 24969 were without effect. 3. Ketanserin (pA 2 = 5.65) was a competitive antagonist of the effects of 5-HT, MK212 and methysergide. 4. Mianserin (pA 2 = 6.3) was also a competititve antagonist of 5-HT but ICS 205-930 had no antagonistic effect on 5-HT-induced relaxation. 5. It is concluded that 5-HT relaxes the locust foregut by interacting with 5-HT 2-like receptors.

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