Affordable Access

Publisher Website

Effect of local GABA administration on rat ovarian blood flow, and on progesterone and estradiol secretion

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
111
Issue
3
Identifiers
DOI: 10.1016/0014-2999(85)90650-8
Keywords
  • Gaba
  • Rat Ovary
  • Pseudopregnant
  • Progesterone
  • Estradiol-17-β
  • Ovarian Blood Flow

Abstract

Abstract The effect of γ-aminobutyric acid (GABA) — superfused onto the surface of the ovary — on ovarian blood flow and on estradiol-17-β (E 2) and progesterone (P) secretion was studied in anaesthesized, pseudopregnant rats. GABA, 0.5 μmol per 50 μl per animal, significantly reduced the blood pressure in the femoral artery, increased ovarian blood flow, enhanced the rate of E 2 release and markedly decreased P secretion. The present findings indicate that local GABAergic mechanisms may be involved in the regulation of ovarian blood flow and hormone secretion.

There are no comments yet on this publication. Be the first to share your thoughts.