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Modern Management of Clinical Chorioamnionitis

Authors
Journal
Infectious Diseases in Obstetrics and Gynecology
1064-7449
Publisher
Hindawi Publishing Corporation
Publication Date
Volume
3
Issue
3
Identifiers
DOI: 10.1155/s1064744995000457
Keywords
  • Research Article
Disciplines
  • Biology
  • Design
  • Medicine

Abstract

Clinical chorioamnionitis continues to contribute to fetal and maternal morbidity and mortality. Significant advances have been made in the last 20 years in understanding the pathophysiologic processes leading to chorioamnionitis. This review addresses the history, incidence, pathophysiology, host defenses, risk factors, diagnosis, and maternal and neonatal management of clinically evident chorioamnionitis. After a detailed review of the physiologic processes leading to clinical chorioamnionitis and sepsis, we present a modern management scheme designed to optimize perinatal outcome for both mother and fetus.

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