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Cellular inflammatory responses: Novel insights for obesity and insulin resistance

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
53
Issue
6
Identifiers
DOI: 10.1016/j.phrs.2006.03.003
Keywords
  • Insulin Resistance
  • Obesity
  • Diabetes
  • Cellular Inflammatory Response
  • Chronic Inflammation
Disciplines
  • Ecology
  • Geography
  • Medicine

Abstract

Abstract Type 2 diabetes is rapidly becoming a worldwide epidemic. Obesity and sedentary lifestyle are the main environmental causes for the development of insulin resistance and type 2 diabetes. In the past decade, it has been increasingly recognized that obesity and insulin resistance are associated with chronic, low-grade systemic inflammation. This review will cover the recent advances in this field and provide a working model explaining how cellular inflammatory responses arise to cope with obesity-induced metabolic stresses and how these inflammatory responses underlie insulin resistance.

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