Abstract A modelling study with the on-line coupled Eulerian chemical-weather model WRF/Chem for the Southern Italian region around Cosenza (Calabria) was conducted to identify the influences of synoptic scale meteorology, local scale wind systems and local emissions on ozone concentrations in this orographically complex region. Four periods of 5–7 days were chosen, one from each season, which had wind pattern characteristics representative of typical local climatological conditions, in order to study the local versus non-local impacts on ozone transport and formation. To account for the complex terrain, the horizontal resolution of the smallest modelling domain was 3 km. Model results were compared with measurements to demonstrate the capability of the model to reproduce ozone concentrations in the region. The comparison was favourable with a mean bias of −1.1 ppb. The importance of local emissions on ozone formation and destruction was identified with the use of three different emission scenarios. Generally the influence of regional emissions on the average ozone concentration was small. However during periods when mountain-sea wind systems were well developed and synoptic scale winds were weak, the influence of local emissions from the urban area was at its greatest. The maximum influence of local emissions on ozone concentrations was 18 ppb.