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Systemic Lupus Erythematosus: Genomics, Mechanisms, and Therapies

Clinical and Developmental Immunology
Hindawi Limited
Publication Date
DOI: 10.1155/2012/926931
  • Editorial
  • Medicine


Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 926931, 2 pages doi:10.1155/2012/926931 Editorial Systemic Lupus Erythematosus: Genomics, Mechanisms, and Therapies Antonio Ferna´ndez-Nebro,1 Sara Marsal,2 Winn Chatham,3 and Anisur Rahman4 1Rheumatology Department, University of Ma´laga (UMA), Ma´laga, Spain 2Grup de Recerca de Reumatologia, Institut de Recerca, Hospital Vall d’Hebron, Barcelona, Spain 3Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35226, USA 4Centre for Rheumatology, Division of Medicine, University College London, London, UK Correspondence should be addressed to Antonio Ferna´ndez-Nebro, [email protected] Received 31 May 2012; Accepted 31 May 2012 Copyright © 2012 Antonio Ferna´ndez-Nebro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Systemic lupus erythematosus (SLE) is a complex disease caused by complex interactions between genes and the envi- ronment (sex, age, hormones, smoking, infections, drugs, and abnormalities of both the innate and adaptive immune systems). To understand the mechanisms that regulate these interactions and the processes responsible for an immune system that is increasingly autoreactive, it is essential to definitively control lupus and related disorders. Although the prevalence of SLE among East Asians is higher than among Europeans [1], most genomes wide asso- ciation studies (GWAS) have been conducted on populations of European descent. Through multinational collaborations, these studies have achieved large sample sizes and consider- able statistical power. Although the sample sizes of genetic studies in East Asians are generally much smaller than those in Europeans, some have yielded new candidate loci and copy number variations [2, 3]. However, i

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