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TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β

Authors
Journal
The International Journal of Biochemistry & Cell Biology
1357-2725
Publisher
Elsevier
Publication Date
Volume
39
Issue
12
Identifiers
DOI: 10.1016/j.biocel.2007.06.004
Keywords
  • Tgfbi
  • βIg-H3
  • Fas1 Domain
  • Integrin
  • Cell Adhesion
  • Tumorigenesis
  • Angiogenesis
  • Inflammation
  • Osteogenesis
  • Nephropathy
  • Wound Healing
Disciplines
  • Biology
  • Medicine

Abstract

Abstract TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation.

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