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Evaluation of semi-quantitative dynamic contrast-enhanced MRI parameters for prostate cancer in correlation to whole-mount histopathology

Authors
Journal
European Journal of Radiology
0720-048X
Publisher
Elsevier
Volume
81
Issue
3
Identifiers
DOI: 10.1016/j.ejrad.2011.01.107
Keywords
  • Dynamic Contrast-Enhanced Mri
  • Semi-Quantitative Parameters
  • Prostatic Carcinoma
  • Radiotherapy
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Purpose To evaluate the use of semi-quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters for the detection of prostatic carcinoma in correlation to whole-mount histopathology. Materials and methods Fifty-three patients with biopsy-proven prostate cancer were examined by DCE-MRI at 1.5-T. Cancerous and benign prostatic tissue regions of interest were delineated based on the histopathology of whole-mount sections and several semi-quantitative parameters were calculated: time to peak (TTP), maximal contrast enhancement (Cpeak), speed of contrast uptake (Wash-in) and clearance rate of the contrast agent (Wash-out). The area under the ROC curve was determined for each parameter. Results Within individual patients, a consistently higher Cpeak and faster Wash-in were present in cancerous compared to benign prostatic tissue. Both the TTP and the Wash-out occurred more rapidly in tumour tissue than in normal prostatic tissue. Despite a considerable inter-patient overlap of parameter values between tumour and normal prostatic tissue, area under the ROC curve analysis demonstrated that the Wash-in was a good discriminator for cancer and benign tissue (AUC 0.82). Combination of the Wash-in and the Wash-out proved to be even more accurate (AUC 0.87) to discriminate between cancerous and benign prostatic regions. Conclusion The Wash-in is a useful parameter for prostate cancer detection by DCE-MRI.

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