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N-(substituted-phenyl) piperazines: antagonists with high binding and functional selectivity for dopamine D4receptors

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
6
Issue
11
Identifiers
DOI: 10.1016/0960-894x(96)00198-9

Abstract

A series of piperazine derivatives has been prepared as selective antagonists of the dopamine D 4 receptor. Many of the compounds demonstrate a high binding selectivity for D 4 over D 2 receptors. High functional (antagonist) selectivity ( D 4 D 2 ) is shown for 24.

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