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May antihistone antibodies replace antinuclear antibodies (ANA) as a predictor of uveitis in Juvenile idiopathic arthritis?

Authors
Journal
Pediatric Rheumatology
1546-0096
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
6
Identifiers
DOI: 10.1186/1546-0096-6-s1-p4
Keywords
  • Poster Presentation
Disciplines
  • Medicine

Abstract

1546-0096-6-S1-P4.fm BioMed Central Page 1 of 1 (page number not for citation purposes) Pediatric Rheumatology Open AccessPoster presentation May antihistone antibodies replace antinuclear antibodies (ANA) as a predictor of uveitis in Juvenile idiopathic arthritis? EB Nordal*1, NT Songstad2, B Straume3, L Berntson4 and M Rygg5 Address: 1Department of Pediatrics, University Hospital of North Norway and Institute of Community Medicine, University of Tromsø, Tromsø, Norway, 2Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway, 3Institute of Community Medicine, University of Tromsø, Tromsø, Norway, 4Department of Women's and Children's Health, Uppsala University Children's Hospital, Uppsala, Sweden and 5Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway * Corresponding author Background Antihistone antibodies (AHA) are an ANA subtype reported to be associated with uveitis in Juvenile idio- pathic arthritis (JIA). Enzyme-linked immunoassays (E- ANA) are increasingly used as a more standardized alter- native to the immunofluorescense method on Hep-2 cells (IF-ANA). E-ANA, however, show no association with uveitis and should not be used in the diagnostic work-up of JIA. Materials and methods Sera of 100 children with JIA and 60 healthy children were analyzed for antihistone IgM/IgG (Pharmacia ELIA kit), for E-ANA and IF-ANA. Patients were recruited prospec- tively and followed at regular intervals from onset of dis- ease in 1997–2004. Results Of the 100 children with JIA, 16 developed asymptomatic chronic uveitis; mean observation time was seven years. Antihistone IgM/IgG > 30 U/ml were found in six of the 100 children with JIA, four of whom developed uveitis, and in one of the controls. However, exploring lower cut- off levels of AHA, we found uveitis in 13 of 44 patients with AHA > 8 U/ml. Analyses of predictors for u

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