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Synthesis and utility of 5-Thiocyanato deoxyuridine and uridine phosphoramidites as masked synthons

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
33
Issue
42
Identifiers
DOI: 10.1016/s0040-4039(00)60938-3

Abstract

Abstract 5-Thiocyanato-2′-deoxyuridine and 5-thiocyanato-uridine phosphoramidites have been synthesized and incorporated into DNA and RNA trimers via automated methodology. The SCN group has been removed with DTT treatment, and a photocrosslinking aryl azide has been added to the DNA trinucleotide through the resulting thiol group.

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