Affordable Access

Publisher Website

Interaction of a synthetic peptide of the interferon α2 C-terminal part with human blood leukocytes. II. Effect on protein tyrosine phosphorylation

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
296
Issue
3
Identifiers
DOI: 10.1016/0014-5793(92)80302-w
Keywords
  • Interferon α2
  • Synthetic Peptide
  • Human
  • Lymphocyte
  • Tyrosine Phosphorylation
  • Monoclonal Antibody
Disciplines
  • Biology

Abstract

Abstract Tyrosine phosphorylation in human blood lymphocytes was studied as a function of stimulation with concanavalin A (ConA) and treatment of the cells with interferon α2 (IFNα2) and/or an IFN-derived C-terminal synthetic peptide 2438 (amino acid residues 124–138). Both IFNα2 and the peptide 2438 decreased the level of protein tyrosine phosphorylation in the ConA-stimulated cells. In unstimulated cells, IFNα2 increased, and the peptide 2438 decreased the level of the tyrosine phosphorylation. A possible correlation of these effects with stimulation or cell proliferation is discussed.

There are no comments yet on this publication. Be the first to share your thoughts.