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Synthesis of star-shaped block copolymers of ε-caprolactone and d- or l-lactide

Національний університет “Львівська політехніка”
Publication Date
  • Copolymer
  • ε-Caprolactone
  • Biomedical
  • Properties
  • Agricultural Science
  • Biology
  • Chemistry
  • Medicine
  • Pharmacology


247 SYNTHESIS OF STAR-SHAPED BLOCK COPOLYMERS OF ε-CAPROLACTONE AND D- OR L-LACTIDE J. Łukaszczyk1, P. Jelonek1, B. Trzebicka2 1Silesian University of Technology, Department of Physical Chemistry and Technology of Polymers, Gliwice, Poland 2Polish Academy of Sciences, Centre of Polymer and Carbon Materials, Zabrze, Poland Synthetic homo- and copolymers of ε-caprolactone (CL) and lactide (LA) are increasingly investigated world-wide for biomedical, pharmacological and agricultural purpose because of their excellent biodegradability and biocompatibility. Branched star-shaped polyesters have attracted even more attention because of their interesting physical (rheological, mechanical) and chemical properties. They exhibit lower crystallinity, lower melt viscosity and higher end-group functionality if compared to linear analogues. The effective method of synthesis of star-shaped homo- and copolymers of CL and LA is ring opening polymerization (ROP) of these cyclic esters. Many organometallic derivatives have been successfully used as catalyst for ROP of CL and LA, among them stannous octoate (SnOct2) is the most widely used one due to its high efficiency and other advantages. It produces in high yield aliphatic polyesters with relatively small dispersity and enables molar mass control. Moreover, due to coordination-insertion mechanism of the reaction, SnOct2 can reduce or eliminate side reactions like inter- and intramolecular transesterification. Additional advantages of stannous octoate catalyst are: good solubility in common organic solvents and cyclic esters and the fact that the American Food and Drug Administration (FDA) has accepted it as food additive, what is important for potential biomedical applications of synthesized polymers. A series of star-shaped, hydroxyl-terminated block copolymers of CL and LA (D- or L-LA) was synthesized through sequential ROP of CL and D- or L-LA in the presence of SnOct2 catalyst and multifunctional initiators -

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