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Pseudotyping Lentiviral Vectors with Aura Virus Envelope Glycoproteins for DC-SIGN–Mediated Transduction of Dendritic Cells

Authors
Journal
Human Gene Therapy
1043-0342
Publisher
Mary Ann Liebert
Publication Date
Volume
22
Issue
10
Identifiers
DOI: 10.1089/hum.2010.196
Keywords
  • Methods
Disciplines
  • Biology

Abstract

Froelich and colleagues report that pseudotyping lentiviral vectors (LVs) with envelope glycoproteins from the Aura virus alphavirus results in LVs that use C-type lectins such as DC-SIGN as attachment factors. These pseudotyped LVs exhibit marked preferential transduction of DC-SIGN receptor-expressing dendritic cells (DCs) over other cell types, highlighting their potential for genetically modifying DCs.

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