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Evaluation of antiplaque activity ofAzadirachta indicaleaf extract gel—a 6-week clinical study

Authors
Journal
Journal of Ethnopharmacology
0378-8741
Publisher
Elsevier
Publication Date
Volume
90
Issue
1
Identifiers
DOI: 10.1016/j.jep.2003.09.035
Keywords
  • Gels
  • Neem
  • Azadirachta Indica
  • Chlorhexidine
  • Plaque Index
  • Salivary Microbial Count
Disciplines
  • Chemistry

Abstract

Abstract Various chemical agents have been evaluated over the years with respect to their antimicrobial effects in the oral cavity; however, all are associated with side effects that prohibit regular long-term use. Therefore, the effectiveness of neem ( Azadirachta indica A. Juss) leaf extract against plaque formation was assessed in males between the age group of 20–30 years over a period of 6 weeks. Present study includes formulation of mucoadhesive dental gel containing Azadirachta indica leaf extract (25 mg/g). A 6-week clinical study was conducted to evaluate the efficacy of neem extract dental gel with commercially available chlorhexidine gluconate (0.2% w/v) mouthwash as positive control. Microbial evaluation of Streptococcus mutans and Lactobacilli species was carried out to determine the total decrease in the salivary bacterial count over a period of treatment using a semi-quantitative four quadrant streaking method. The results of the study suggested that the dental gel containing neem extract has significantly ( P<0.05) reduced the plaque index and bacterial count than that of the control group.

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