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Spectroscopical study of bacteriopurpurinimide–naphthalimide conjugates for fluorescent diagnostics and photodynamic therapy

Authors
Journal
Journal of Photochemistry and Photobiology B Biology
1011-1344
Publisher
Elsevier
Publication Date
Volume
133
Identifiers
DOI: 10.1016/j.jphotobiol.2014.03.008
Keywords
  • 1
  • 8-Naphthalimide
  • Bacteriopurpurinimide
  • Conjugate
  • Photodynamic Therapy
  • Fluorescence Imaging
  • Resonance Energy Transfer
  • Pm6 Semiempirical Calculations
Disciplines
  • Design
  • Medicine

Abstract

Abstract Two novel bis(chromophoric) dyads ABPI–NI1 and ABPI–NI2 containing 1,8-naphthalimide and bacteriopurpurinimide units linked by p-phenylene-methylene (ABPI–NI1) and pentamethylene (ABPI–NI2) spacers were prepared to test their ability to be used in the design of effective agents for both photodynamic therapy (PDT) and fluorescent tumor imaging. Photophysical studies revealed that the emission from the naphthalimide chromophore in both conjugates was partially quenched due to resonance energy transfer between the photoactive components. Compound ABPI–NI2 with more sterically flexible oligomethylene group demonstrated higher fluorescence intensity as compared with that for ABPI–NI1.

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