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Experimental allergic encephalomyelitis: Simple method for producing the localized form

Authors
Journal
Journal of Immunological Methods
0022-1759
Publisher
Elsevier
Publication Date
Volume
54
Issue
3
Identifiers
DOI: 10.1016/0022-1759(82)90319-2
Keywords
  • Experimental Allergic Encephalomyelitis
  • Passive Transfer
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract In the past, the lesions of experimental allergic encephalomyelitis (EAE) have been induced to localize around brain tissue damaged by anoxia or direct physical or chemical attack. The procedure for producing the requisite antecedent brain injury has been simplified by use of a single subcutaneous injection of a neurotoxic chemical, thereby eliminating the need for surgery. The EAE lesions are concentrated in a very small area and can be obtained in one day after the passive transfer of a relatively small number of lymph node cells from immunized donors.

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