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Editors’ Pick: Normal aging versus Alzheimer’s disease – expression patterns may discern the differences

Investigative Genetics
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/2041-2223-3-11
  • Editorial
  • Biology
  • Medicine
  • Social Sciences


1717790607715780 1..1 EDITORIAL Open Access Editors’ Pick: Normal aging versus Alzheimer’s e sion patterns that explained the largest component of Budowle Investigative Genetics 2012, 3:11 Genetics, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA variance among the cohorts. The other three metagene groups - Alz (Alzheimer), Inflame (inflammation), and NdStress (neurodegenerative stress) - contribute less than BioAge but all together allow for detection of novel molecular biomarkers for prediction and prognosis of AD progression. The authors suggest, and rightly so, that “AD can be viewed as an aberrant aging of the Molecular Insights into the Pathogenesis of Alzheimer’s Disease and Its Relationship to Normal Aging. PLoS ONE 2011, 6:e29610. doi:10.1186/2041-2223-3-11 Cite this article as: Budowle: Editors’ Pick: Normal aging versus Alzheimer’s disease – expression patterns may discern the differences. Investigative Genetics 2012 3:11. Correspondence: [email protected] Institute of Investigative Genetics, Department of Forensic and Investigative disease – expression patt the differences Bruce Budowle* “The Times They Are a-Changin’,” one of Bob Dylan’s albums of the 1960’s, reflected the social change of the time. These same words reflect science today as it has and continues to change, providing advances that once would have been thought to be impossible or would re- quire monumental efforts as applied to the human gen- ome project. These tools will have a tremendous impact on society and individuals with a promise of improving the quality of life. An example of the possibilities that the wave of molecular biology advances affords is the recent publication by Podtelezhnikov et al. [1]. They show convincingly the value of the technology of ex- pression arrays for studying pathways of complex dis- eases, such as Alzheimer’s disease (AD), that may affect many of

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