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Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo

Authors
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Elsevier BV
Publication Date
Keywords
  • Fucoidan Is Known To Exhibit Crucial Biological Activities
  • Including Anti-Tumor Activity
  • In This Study
  • We Examined The Influence Of Crude Fucoidan Extracted From Sargassum Sp
  • (Mta) And Fucus Vesiculosus (Sig) On Lewis Lung Carcinoma Cells (Lcc) And Melanoma B16 Cells (Mc)
  • In Vitro Studies Were Performed Using Cell Viability Analysis And Showed That Sig And Mta Fucoidans
  • Histochemical Staining Showed Morphological Changes Of Melanoma B16 Cells After Exposure To Fucoidan
  • The Observed Changes Were Indicative Of Crude Fucoidan Induced Apoptosis
  • Male C57Bl/6Jjcl Mice Were Subjected To Daily I
  • P
  • Injections Over 4 Days With Either Sig Or Mta Fucoidan (50 Mg/Kg Body Wt
  • )
  • The Cytolytic Activity Of Natural Killer (Nk) Cells Was Enhanced By Crude Fucoidan In A Dose-Depende
  • This Study Provides Substantial Indications That Crude Fucoidan Exerts Bioactive Effects On Lung And

Abstract

Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo - DTU Orbit (15/04/14) Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo - DTU Orbit (15/04/14) Ale, Marcel Tutor; Maruyama, Hiroko; Tamauchi, Hidekazu; Mikkelsen, Jørn Dalgaard; Meyer, Anne S. / Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo. In: International Journal of Biological Macromolecules, Vol. 49, 2011, p. 331-336. Publication: Research - peer-review › Journal article – Annual report year: 2011

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