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DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

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BIOMED CENTRAL LTD
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  • Medicine And Health Sciences

Abstract

Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.

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