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Design of DNA-cleaving molecules which incorporate a simplified metal-complexing moiety of bleomycin and lexitropsin carriers

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
3
Issue
8
Identifiers
DOI: 10.1016/s0960-894x(00)80056-6

Abstract

Abstract The syntheses of 1a-c, functional models for bleomycin, which are composed of a simplified metal-complexing moiety of bleomycin and poly-N-methylpyrrole peptides are described. Their functional cleavage of DNA in the presence of reductants is demonstrated.

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