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Aorta Remodeling Responses to Distinct Atherogenic Stimuli: Hyperten-sion, Hypercholesterolemia and Turbulent Flow/Low Wall Shear Stress

Authors
Publisher
Bentham Open
Publication Date
Volume
2
Issue
1
Identifiers
DOI: 10.2174/1874192400802010041
Keywords
  • Article
Disciplines
  • Physics

Abstract

This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-β expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

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