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Inhibitory effects of Ledebouria ovaltifolia (hyacithaceae) aqueous root extract on contractile responses of Rat Vas deferens to K and adrenaline, pendular movement of isolated rabbit jejunum and acetic acid induced pain in Mice.

Bioline for the Ibadan Biomedical Communications Group
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  • Biology
  • Pharmacology


To investigate the pharmacological effects of aqueous root extract of Ledebouria ovaltifolia on Potassium and Adrenaline-induced contractions of the rat vas deferens, the spontaneous pendular movement of Isolated rabbit jejunum, and acetic acid induce pain in mice. Isolated epidydymal end of the adult male rat{200-350g],and rabbit jejunum in separate experiment were mounted in Ugo Basil organ bath containing Tyrode solution aerated with95% O2 and 5% CO2, and responses monitored through isometric transducer connected to a 2-channel dynamometer recorder The effect of extract[27.4mg/ml] was examined on submaximal dose of K & ,adrenaline, and rabbit pendular movement , similarly the extract was examined on acetic acid induced pain in mice. The extract in concentration used, produce a significant inhibition on K and Adrenaline induced contractions [height] up to 75 and 68% respectively. In most of the experiments and this effect was more marked on K than Adrenailne contractions. The extract showed initial potentiation of PDM, followed by a stepwise relaxation leading to a prolonged cessation of pendular movement thus showing dual actions., the extract prolonged the reaction time of75%[ p>0.05] over 20min observation time with no overt signs of toxicity. These results suggest the presence of spasmolytic and analgesic activities in the plant extract.(Afr. J. Biomed. Res. 10: 89 - 93, January 2007)Keywords: Ledebouria ovaltifolia, rat vas deferens,rabbit jejunum, KCl, adrenaline,

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