Affordable Access

Publisher Website

Evidence for an immune response in major depression: A review and hypothesis

Authors
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
0278-5846
Publisher
Elsevier
Publication Date
Volume
19
Issue
1
Identifiers
DOI: 10.1016/0278-5846(94)00101-m
Keywords
  • Acute Phase Response
  • Cellular And Humoral Immunity
  • Depression
  • Inflammation
  • Interleukin-1β
  • Interleukin-6
  • Psychoneuroimmunology
Disciplines
  • Biology

Abstract

Abstract 1. 1. This paper reviews recent findings on cellular and humoral immunity and inflammatory markers in depression. 2. 2. It is shown that major depression may be accompanied by systemic immune activation or an inflammatory response with involvement of phagocytic (monocytes, neutrophils) cells, T cell activation, B cell proliferation, an “acute” phase response with increased plasma levels of positive and decreased levels of negative acute phase proteins, higher autoantibody (antinuclear, antiphospholipid) titers, increased prostaglandin secretion, disorders in exopeptidase enzymes, such as dipeptidyl peptidase IV, and increased production of interleukin (IL)-1β and IL-6 by peripheral blood mononuclear cells. 3. 3. It is hypothesized that increased monocytic production of interleukins (Il-1β and Il-6) in severe depression may constitute key phenomena underlying the various aspects of the immune and “acute” phase response, while contributing to hypothalamic-pituitary-adrenalaxis hyperactivity, disorders in serotonin metabolism, and to the vegetative symptoms (i.e. the sickness behavior) of severe depression.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Evidence for an immune response in major depressio...

on Progress in Neuro-Psychopharma... January 1995

Immune dysregulation in major depression: a critic...

on The international journal of n... December 2002

A review on the acute phase response in major depr...

on Reviews in the neurosciences 1993

Immune–endocrine host response to endotoxin in maj...

on Journal of Psychiatric Researc... Jan 01, 2007
More articles like this..