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Presenile dementia: some pathological problems and possibilites.

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  • Research Article
  • Medicine


NEUROLOGY2013567784 34..35 DOI 10.1212/WNL.0000000000000158 2014;82;e34-e35 Neurology John C.S. Breitner findings Mild cognitive impairment and progression to dementia: New This information is current as of January 27, 2014 located on the World Wide Web at: The online version of this article, along with updated information and services, is Neurology. All rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X. since 1951, it is now a weekly with 48 issues per year. Copyright © 2014 American Academy of ® is the official journal of the American Academy of Neurology. Published continuouslyNeurology PATIENT PAGE Section Editors David C. Spencer, MD Steven Karceski, MD John C.S. Breitner, MD, MPH Mild cognitive impairment and progression to dementia New findings WHAT WERE THE MAIN FINDINGS? Dr. Roberts and colleagues1 examined 2,719 elderly residents of Olmstead County, MN, every 15 months. The exami- nations showed that 534 persons had mild cognitive impairment, or MCI (see About MCI, following sec- tion). Some people hadMCI when they were first seen. Others developed the condition later, so their prob- lems were discovered during follow-up exams. The doctors knew from earlier studies that many people with MCI go on to develop dementia after a few years. But other people show little change over this time, while still others seem to recover or “revert” to cognitively normal when next examined. The doctors found that almost 40% of people with MCI “reverted” in this last way (a typical result). They wanted to know whether these “reverters” differed from other cognitively normal people in their risk of dementia. Over about 5 years of observation, they found that 65% of the “reverters” did go on to develop dementia. That was about 6 times the percentage of other cognitively normal people. WHAT SETS THESE FINDINGS APART FROM EARLIER WORK? There aren’t many reliable studies of what happens to people who “

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