Mitochondrial defects in cancer

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Mitochondrial defects in cancer

Authors
Publisher
BioMed Central Ltd.
Keywords
  • Cancer
  • Respiration
  • Mutation
  • Mitochondria
  • Free Radical

Abstract

Abstract Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional consequences in cancer development, and therapeutic implications.

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