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Review of "Systems Biology in Practice" by Edda Klipp, Ralf Hertwig, Axel Kowald, Christoph Wierling and Hans Lehrach

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Abstract ral Theoretical Biology and Medical ss BioMed CentModelling Open AcceBook review Review of "Systems Biology in Practice" by Edda Klipp, Ralf Hertwig, Axel Kowald, Christoph Wierling and Hans Lehrach Paul S Agutter* Address: Theoretical and Cell Biology Consultancy, 26 Castle Hill, Glossop, Derbyshire, UK Email: Paul S Agutter* - [email protected] * Corresponding author Book details Klipp E, Herwig R, Kowald A, Wierling C, Lehrach H: Systems Biology in Practice Berlin: Wiley-VCH; 2005. 449 pages, ISBN- 10 3-527-31078-9, ISBN-13 978-3-527-31078-4. Eur 99.00 hardback Systems biology – the study of such functional networks as cellular metabolism, signalling and gene expression – is a rapid growth area, as illustrated by many recent publica- tions in Theoretical Biology and Medical Modelling and other journals. Its emergence has been fostered by the develop- ment of automated, high-throughput techniques such as DNA microarrays, of the ever-increasing storage capacity and calculating speed of computers, of new mathematical tools, and of modern electronic communications. Its impact on biological research is already evident: tradi- tional data (e.g. the results of single-gene studies) are being reinterpreted in a broader cellular context, radically new research strategies are appearing, novel insights into the integration of cell systems are being gained, and the prospects for advances in medicine, biotechnology, ecol- ogy and other areas of applied science and technology seem, to the optimistic, almost limitless. To write a book surveying the concepts, methods and potential applica- tions of this nascent though already wide field was a chal- lenging enterprise, but the authors of Systems Biology in Practice have largely achieved their objective. This is a timely volume that should be welcomed both by practis- ing systems biologists and by newcomers to the field. The book is divided into three parts. Part I (chapters 1–4), imental techniques. Par

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