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Effects of nematode infection on sensitivity to intestinal distension: Role of tachykinin NK2receptors

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
337
Identifiers
DOI: 10.1016/s0014-2999(97)01275-2
Keywords
  • Intestinal Distension
  • Visceral Hyperalgesia
  • Visceral Nociception
  • Mast Cell
  • Tachykinin
  • Tachykinin Nk2Receptor

Abstract

Abstract Distension of the rat intestine causes a depressor response which is predictive of nociception. This study investigated the effects of previous infection with Nippostrongylus (N.) brasiliensis on the sensitivity to intestinal distension and the role of tachykinin NK 2 receptors. The tachykinin NK 2 receptor antagonist, SR48968 ( S)- N-methyl- N[4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl]benzamide) inhibited the nociceptive response (ED 50=0.7 mg/kg) in control rats. In post- N. brasiliensis-infected rats sensitivity to intestinal distension was increased which was accompanied by an increase in the apparent potency value of SR48968 (ED 50=0.1 mg/kg). The hypersensitivity was limited to areas of hypermastocytosis. It is concluded that the post-inflammatory changes that occur in post-infected rats increase visceral sensitivity and the apparent potency of tachykinin NK 2 receptor antagonists.

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