Affordable Access

Publisher Website

l-Homoserine: a novel excreted metabolic marker of hepatitis B abnormally produced in liver from methionine

Authors
Journal
Medical Hypotheses
0306-9877
Publisher
Elsevier
Publication Date
Volume
58
Issue
4
Identifiers
DOI: 10.1054/mehy.2001.1527
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract The hepatitis B infection leads to various profound pathological processes in liver metabolism. Some biochemical alterations detectable by blood analysis are currently used for a preliminary evaluation of the infection. Based on existing data we present here evidence that non-protein amino acid l -homoserine is a pathological, hepatitis B-induced metabolite that is formed and excreted into urine from methionine via splitting S-adenosylmethionine. The urine l -homoserine is proposed as a new marker in the pre-diagnosis examinations that is easier for the clinical analysis than currently used blood test, and is applicable to large-scale epidemiological surveys of the probability of hepatitis B.

There are no comments yet on this publication. Be the first to share your thoughts.