Affordable Access

Publisher Website

Bifunctional mesoporous MCF materials as catalysts in the Friedländer condensation

Authors
Journal
Catalysis Today
0920-5861
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.cattod.2013.04.034
Keywords
  • Mesoporous Materials
  • Niobiosilicates
  • Quinolines
  • Friedländer Reaction
  • Computational Studies
Disciplines
  • Computer Science

Abstract

Abstract We report herein the Friedländer reaction of 2-aminoaryl aldehydes 1 and ethyl acetatoacetate (2) affording the corresponding quinolines 3. The condensation selectively leads to quinolines 3 with good to excellent yields under mild reaction conditions. The first step of the condensation is the Knoevenagel reaction between reagents as experimentally confirmed. In addition, in order to justify our results we carried out a computational study based on DFT calculations analyzing this first step of the condensation. In this sense, we propose a cooperative catalysis mechanism involving the amine functions and metallic centers both of them acting as activating agents of the reagents and, therefore, favoring the process.

There are no comments yet on this publication. Be the first to share your thoughts.