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Calciphylaxis in chronic, non-dialysis-dependent renal disease

Authors
Journal
BMC Nephrology
1471-2369
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
4
Issue
1
Identifiers
DOI: 10.1186/1471-2369-4-8
Keywords
  • Case Report
Disciplines
  • Medicine

Abstract

1471-2369-4-8.fm ral ss BioMed CentBMC Nephrology Open AcceCase report Calciphylaxis in chronic, non-dialysis-dependent renal disease Rainer U Pliquett*1, Jörg Schwock2, Ralf Paschke3 and Harald Achenbach1 Address: 1Department of Nephrology, University of Leipzig, Phillip-Rosenthal-Str. 27, Leipzig, Germany, 2Department of Pathology, University of Leipzig, Liebig-Str. 26, Leipzig, Germany and 3Internal-Medicine Department III, University of Leipzig, Phillip-Rosenthal-Str. 27, Leipzig, Germany Email: Rainer U Pliquett* - [email protected]; Jörg Schwock - [email protected]; Ralf Paschke - [email protected]; Harald Achenbach - [email protected] * Corresponding author Abstract Background: Calciphylaxis cutis is characterized by media calcification of arteries and, most prominently, of cutaneous and subcutaneous arterioles occurring in renal insufficiency patients. Case Report: A 53-year-old woman with chronic cardiac and renal failure complained of painful crural, non-varicosis ulcers. She was hospitalized in an immobilized condition due to both the crural ulcerations and the existing heart-failure state (NYHA III-IV) having pleural and pericardial effusions, atrial fibrillation and weight loss of 30 kg over the past year. Despite normalization of calcium-phosphorus balance and improvement of renal function, the clinical course of crural ulcerations deteriorated during the following 3 months. After failure of surgical debridements, multiple courses of sterile-maggot therapy were introduced at a late stage to stabilize the wounds. The patient died of recurrent wound infections and sepsis paralleled by exacerbations of renal malfunction. Conclusions: The role of renal disease in vascular complications is discussed. Sterile-maggot debridement may constitute a therapy for the ulcerated calciphylaxis at an earlier stage, i.e. when first ulcerations appear. Background Calciphylaxis cutis is characterized by media calcification of arteries and, most p

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