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The effect of acute hypoxia on right ventricular function in healthy adults

Authors
Journal
International Journal of Cardiology
0167-5273
Publisher
Elsevier
Publication Date
Volume
31
Issue
2
Identifiers
DOI: 10.1016/0167-5273(91)90221-a
Keywords
  • Imaging

Abstract

Abstract Right ventricular ejection fraction and right ventricular volumes were derived in 12 healthy male subjects using krypton-81m equilibrium radionuclide ventriculography whilst subjects breathed 30% (high inspired oxygen) and then 8–12% oxygen in nitrogen mixture (hypoxia). ‘Physiological’ tricuspid valve regurgitation was identified in 7 of the subjects by Doppler echocardiography, and right ventricular peak systolic pressure was estimated during high inspired oxygen and during hypoxia. Mean right ventricular peak systolic pressure was 24.1 ± 3.3 mmHg during high inspired oxygen and increased to 41.3 ± 8.4 mmHg during hypoxia ( P < 0.01). Mean right ventricular ejection fraction was 0.612 ± 0.075 during high inspired oxygen and was unchanged at 0.590 ± 0.073 during hypoxia. There was no significant change in right ventricular end-diastolic volume or stroke volume in response to hypoxia. The systolic performance of the normal right ventricle is well-maintained during an acute rise in afterload induced by hypoxia.

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