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Application of single-molecule sensing for medical diagnostics

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Microsoft Word - Dissertation A.WILDFINALII .doc 1 APPLICATION OF SINGLE-MOLECULE SENSING FOR MEDICAL DIAGNOSTICS INAUGURALDISSERTATION zur Erlangung der Würde eines Doktors der Philosophie vorgelegt der Philosophisch-Naturwissenschaftlichen Fakultät der Universität Basel von Andreas Wild aus Wattwil SG Basel, 2006 2 Genehmigt von der Philosophisch-Naturwissenschaftlichen Fakultät der Universität Basel auf Antrag der Herren Prof. Dr. phil. II Ueli Aebi Prof. Dr. phil. II Bert Hecht Prof. Dr. med. Josef Flammer Basel, den 2. Mai 2006 Prof. Dr.Hans-Jakob Wirz, Dekan 3 To my parents and my sister 4 Table of Contents Table of Contents..................................................................................... 4 1. Introduction .......................................................................................... 6 1.1 References .......................................................................................10 2. Novel method for the detection of fluorophores in liquids ............ 11 2.1 Introduction ............................................................................................11 2.2 Materials and Methods.........................................................................12 2.2.1 Experimental Setup.......................................................................12 2.2.2 Design of FRET molecules ..........................................................15 2.2.3 Wavelength shifting and filter design .........................................16 2.2.4 Recording of time traces ..............................................................17 2.2.5 Buffer solution ................................................................................18 2.2.6 Data treatment ...............................................................................18 2.2.

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