Affordable Access

Publisher Website

Reduced anxiety and depression-like behavior in synaptotagmin IV (−/−) mice

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
47
Issue
4
Identifiers
DOI: 10.1016/j.neuropharm.2004.05.008
Keywords
  • Synaptotagmins
  • Hippocampus
  • Anxiolytic
  • Inhibitor
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract Synaptotagmin IV (Syt IV) is a secretory vesicle protein that is broadly expressed in brain and may function as a presynaptic regulator of synaptic release. Because Syt IV and abnormalities in neurotransmission have been implicated in psychiatric disease, we examined Syt IV (−/−) mice in animal models of mood-related behavior. We report that Syt IV (−/−) mice display lower levels of anxiety-like behavior in the elevated plus maze and enhanced locomotion in the open field. Syt IV (−/−) mice also exhibit reduced depression-like behavior and are highly sensitive to the effects of the anti-depressant imipramine in a modified Porsolt forced swim test. However, the physical restraint-induced stress hormone response is normal in Syt IV (−/−) mice. As judged by immunohistochemical criteria, the synaptic structure and connectivity of the hippocampus and raphe nucleus in Syt IV (−/−) mice are indistinguishable from wild-type littermates. These results indicate that Syt IV plays a role in rodent mood-related behavior and suggests Syt IV regulates synaptic function in the neuronal networks that modulate these behaviors.

There are no comments yet on this publication. Be the first to share your thoughts.