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Itraconazole in the Treatment of Orbital Aspergillosis

Authors
Journal
Ophthalmology
0161-6420
Publisher
Elsevier
Volume
103
Issue
9
Identifiers
DOI: 10.1016/s0161-6420(96)30482-x
Disciplines
  • Agricultural Science
  • Medicine

Abstract

Background: Sino-orbital aspergillosis is typically treated with surgical debridement and intravenous amphotericin B. Some authors have advocated intraorbital irrigation or injection of amphotericin B in specific cases. Methods: An immunocompetent patient with recurrent sino-orbital aspergillosis is presented. After failing two attempts at traditional therapeutic modalities, treatment with oral itraconazole was initiated. Results: The patient has had resolution of her sino-orbital disease without recurrence at 10 months of follow-up. Conclusion: In immunocompetent patients with orbital aspergillosis, itraconazole should be considered as a treatment option in patients who have recurrent or recalcitrant disease, or in those who cannot tolerate amphotericin B.

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