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Early events in lymphopoiesis: the role of interleukins 1 and 7

Authors
Journal
Journal of Autoimmunity
0896-8411
Publisher
Elsevier
Publication Date
Volume
2
Identifiers
DOI: 10.1016/0896-8411(89)90126-1

Abstract

Abstract This article summarizes evidence that interleukins 1 and 7 play a critical role in the early stages of lymphopoiesis. IL-1 has been demonstrated to be identical to the growth factor previously termed haemopoietin-1 and appears to cause the growth of haemapoietic stem cells. Interleukin-7, originally described as a pre-B-cell growth factor, also has proliferative activity on T cells. It is proposed that IL-7 acts on lymphoid stem cells.

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