Affordable Access

DNA polymerase activity in muscle cultures

The Journal of Cell Biology
The Rockefeller University Press
Publication Date
  • Articles


Nuclei within myotubes do not synthesize DNA for replication. Accordingly, cultures of myotubes display low levels of DNA polymerase activity. The coincidental decline in DNA polymerase activity and increased formation of multinucleated myotubes during culture does not prove that the loss of capacity to synthesize DNA is a consequence of fusion. Tne experiments described demonstrate that myogenic cells prevented from fusing have low levels of DNA polymerase activity. This is consistent with the notion that, in myogenic cultures, there is a population of mononucleated cells, the myoblasts, which have withdrawn from the mitotic cycle before fusion.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

DNA polymerase activity in muscle cultures.

on The Journal of Cell Biology April 1978

Changes in DNA polymerase activity associated with...

on Journal of Cellular Physiology February 1969

[DNA-Polymerase activity in synchronous cell cultu...

on Schweizerische medizinische Wo... Aug 19, 1972

DNA synthesis and DNA polymerase activity in diffe...

on Biochemical and Biophysical Re... Jan 01, 1973
More articles like this..