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Heparin aerosol - effect on blood coagulation and pulmonary function

Authors
Journal
Thrombosis Research
0049-3848
Publisher
Elsevier
Publication Date
Volume
21
Identifiers
DOI: 10.1016/0049-3848(81)90150-x
Keywords
  • Heparin Aerosol
  • Prophylaxis
  • Thromboembolism
  • Antithrombin
Disciplines
  • Medicine

Abstract

Abstract Heparin was administrated as an aerosol in amounts of 700, 1 300 and 2 000 IU per kg body weight to 16 volunteers on 24 occasions. The concentration of heparin was registered with a chromogenic substrate method. An absorption of heparin via the lung was noted and the concentration of heparin was increased (> 0.02 IU/ml) for 2–3 weeks after 15 inhalations. There was a wide variability in response with regard to concentration of heparin, thrombin time and activated partial thromboplastin time. No dose-response relationship was found. The level of antithrombin and platelet count were mainly unchanged. No untoward effects or changes in pulmonary function were seen.

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