[(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity

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[(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity

Authors
Publisher
Wiley-VCH Verlag Berlin
Keywords
  • Biology
  • 540 Chemistry
  • 570 Life Sciences
  • Institute Of Inorganic Chemistry
  • Institute Of Molecular Cancer Research

Abstract

The antischistosomal effect of two [(η(6)-praziquantel)Cr(CO)(3)] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines.

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